PRP has been quite successful in treating knee pain. First off, if there is a significant amount of fluid in the joint, then the excess fluid is aspirated out before any PRP injections are performed. After the excessive synovial fluid has been removed from the knee, then PRP is injected into the knee joint, and also into the ligaments and tendons around the joint too. The PRP is injected into the medial and lateral collateral ligaments, the mensci, the patellar and quadriceps tendon attachments, the biceps femoris tendon, and sometimes deep inside the joint into the anterior and/or posterior cruciate ligaments. The patient needs to remain off the knee as much as possible for the first 48 hours, then no exercise, long walks, deep knee bends, or heavy lifting for two weeks. The knees will usually require about three treatments at 6 to 8 week intervals, but may vary from 2 to 6 treatments to obtain a satisfactory result.